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peanut allergy therapy not yet viable, say researchers
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study gives light at the end of the peanut allergy tunnel
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gradual exposure to peanut may put an end to peanut allergy, if results of a small study from cambridge are followed by similar positive results. scientists from addenbrooke’s hospital in cambridge exposed four peanut-allergic children to gradually increasing quantities of peanut protein, and found that all the children can now tolerate about 800 mg grams of protein, which is the equivalent to five peanuts, per day. dr andy clark and his co-workers report their results of their study in the journal allergy . although the study is small, the implications could essentially be huge. peanut allergies are rising in humans, with an estimated 2.5 million people in europe and the us now vulnerable to the food allergy. there is no current cure for food allergy and vigilance by an allergic individual is the only way to prevent a reaction but a peanut allergy can be so severe that only very tiny amounts can be enough to trigger a response. current recommendations in many countries, such as the uk and the us, for would-be mothers are to avoid peanuts during pregnancy, breastfeeding, and infancy. with peanut allergy potentially fatal for some people, food manufacturers are already bound by certain regulations, depending on the country, to highlight possible allergens in a food product, such as the eu’s labelling directive 2000/13/ec. four children give hope dr clark and his co-workers recruited the four children aged 12, 13, 9, and 13, and investigated if peanut oral immunotherapy (oit) could induce clinical tolerance to peanut protein. an initial challenge confirmed the presence of peanut allergy in the children, with one of them experiencing anaphylaxis that required an injection of adrenaline. these initial tests revealed dose thresholds ranging from five to 50 mg, which is the equivalent to between 0.025 and 0.25 of a peanut. the children then began oit as daily doses of peanut flour. the doses increased fortnightly from 5 to 800 mg of protein. six weeks later, the oral challenge was repeated, and the new dose threshold values calculated. at the same time, subjects continued daily treatment. during the post intervention challenges, the four children were found to tolerate at least 10 whole peanuts, or 2.4 grams of protein, said the researchers. this equated to a dose threshold increase of 48-, 49-, 55- and 478-fold for the four subjects. current state-of-play “each subject is currently tolerating approximately 800 mg protein (five peanuts) per day, and can tolerate at least double that amount on oral challenge,” wrote clark and his co-workers. “tolerance may be lost if subjects were to stop oit at this stage, and it is likely that long-term maintenance is required, as for other forms of immunotherapy. “follow-up studies are therefore required to examine the duration and frequency of maintenance therapy required to induce long-term tolerance,” they concluded. early exposure may be vital a recent study comparing incidence of peanut allergy in jewish children in the uk and israel (where no recommendations for peanut avoidance exist) showed that children in the uk were 10 times more likely to suffer from peanut allergy than their israeli counterparts. findings in the journal of allergy and clinical immunology showed that 69 per cent of israeli children were consuming peanut, while only ten per cent of the children in the uk were eating peanuts. source: allergy published online ahead of print, doi: 10.1111/j.1398-9995.2009.01982.x "successful oral tolerance induction in severe peanut allergy" authors: a. t. clark, s. islam, y. king, j. deighton, k. anagnostou, p. w. ewan
Source :Food Ingredients Food Science - Additives, Flavours, Starch
Date :
20
February
2009
Category :
Fruits And Vegetables
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fears over the dangers of peanut allergy, a potentially deadly allergy for certain people, are becoming sensationalist and hysterical, according to a harvard professor. a level-headed approach is needed before the situation spirals out of control, wrote professor nicolas christakis from harvard medical school in the british medical journal . the food industry is already bound by certain regulations, depending on the country, to highlight possible allergens in a food product, such as the eu’s labelling directive 2000/13/ec.
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avoiding peanuts in infancy and early childhood may increase the risk of developing peanut allergy, says a joint british-israeli study. children in the uk, where recommendations are to avoid peanuts during pregnancy, breastfeeding, and infancy, were 10 times more likely to suffer from peanut allergy than their israeli counterparts, according to a new study published in the journal of allergy and clinical immunology .
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details remain unclear about the claims by a north carolina agricultural and technical state university researcher that he has developed a process to make allergen-free peanuts. the north carolina researcher, mohamed ahmedna, announced last month he has developed a patented process to create allergen-free peanuts. the process would open up new markets for processors and reduce the risk of recall.
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the allergic reaction to cashew nuts is more severe than peanuts, says a new study that deepens our understanding of food allergies and highlights the need for clear labelling. "cashew nuts present a considerable hazard, being hidden in a wide variety of commonly ingested foods, such as asian meals, sweets, ice cream, cakes, chocolates and they are increasingly used in commercially prepared pesto sauce instead of pine nuts," wrote lead author andrew clark in the journal allergy .
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as europe prepares for tougher rules on allergen labeling, a new study has found that allergies to almonds, pecans, cashews and other tree nuts may not be lifelong. the study, conducted by researchers at us based johns hopkins children's center, revealed that nine percent of children outgrow tree nut allergies, including some who have had severe reactions such as anaphylaxis shock.
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as europe prepares for tougher rules on allergen labelling, a new study could help food makers by slicing away the allergenicity of peanut products, reports lindsey partos. an estimated 4 per cent of adults and 8 per cent of children in the eu - the total population tops 380 million - suffer from food allergies, according to the european federation of allergy and airways diseases patients' associations.
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Coca.Cola
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PEPSI
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Mcdonald
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Nestle
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Mars
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Baskin & Robins
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Nutrika
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Mumika
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Chika
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adding 
the number of people who are allergic to 
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