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new obesity research revises the weight loss assumptions
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caloric overload may disrupt brain functions
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consuming too many calories may disturb the pathway in the brain that directly affects food intake and body weight, according to a new study. researchers from the university of wisconsin-madison report that the too much food or energy consumption leads to a problem called metabolic inflammation, according to findings from the mice studies. "metabolic inflammation is a chronic, low-grade condition consisting of inflammatory-like responses at the molecular level. it has many downstream consequences," said researcher dongsheng cai. "it causes cellular dysfunction, which can decrease the regulation of several physiological processes, including metabolism." metabolic inflammation may also be at the core of many chronic, obesity-related metabolic disorders that are so common today, he added. the new research, published in the journal cell , highlights the complex nature of obesity and the possible underlying mechanisms. the food industry has come under increasing pressure to help tackle the rise of obesity. over 300m adults are obese worldwide, according to latest statistics from the who and the international obesity task force. about one-quarter of the us adult population is said to be obese, with rates in western europe on the rise although not yet at similar levels. study details the researchers looked at the hypothalamus – the brain structure responsible for maintaining a energy balance in the body – of mice, and focused on a protein complex called nf-kappab/ ikkbeta. according to the researchers this pathway is much more abundant in the hypothalamus than in peripheral tissue, but it normally remains inactive in the brain. however, a high-fat diet that led to over-nutrition was found to activate ikkbeta/nf-kappab, specifically in neurons in the hypothalamus. this stimulation of the pathway led the animals to increase their energy consumption, while suppressing it helped them maintain normal food intake and body weight. "when we knocked out the ikkbeta gene to suppress nf-kappab activity in these neurons, the animals were significantly protected from energy over-consumption and obesity development," said cai. looking inside the cells in order to understand the mechanism, the researchers found that a cell component called the endoplasmic reticulum (er) underwent stress under conditions of over-nutrition. this stress was the source of the activation of ikkbeta/nf-kappab. suppression of the er stress led to a preservation of the normal regulation of food intake and prevented obesity, said the researchers. while a lot of work still needs to be done, building on these very preliminary findings, cai said that he is maintaining a view of the bigger picture. the key questions left to be answered are: "how does the environment connect to the genetics that seem to underlie the obesity epidemic? what are the key steps that have led to the dramatic rise of diabetes in the past three decades? why can't the body adjust to changes that have occurred in the way people eat and what they eat?" he said.
Source :Food Ingredients Food Science - Additives, Flavours, Starch
Date :
3
October
2008
Category :
Food And Health
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a university of missouri researcher has found that eating a healthy breakfast, especially one high in protein, increases satiety and reduces hunger throughout the day. in addition, using functional magnetic resonance imaging (fmri), the researchers found that eating a protein-rich breakfast reduces the brain signals controlling food motivation and reward-driven eating behavior. “everyone knows that eating breakfast is important, but many people still don’t make it a priority,” said heather leidy, assistant professor in the mu department of nutrition and exercise physiology.
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overweight and obesity are known to dramatically increase the risk of developing heart disease, diabetes, cancer and dementia. excess body fat fuels the fire of systemic inflammation and the release of dangerous chemical messengers or cytokines that damage the delicate inner lining of our arteries; this sets the stage for vascular dysfunction. as we pass age 35, there is a natural tendency to gain weight due to slowing metabolism, unchanged calorie intake and less physical activity.
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nestlé india has signed a memorandum of understanding with the national diabetes, obesity and cholesterol foundation (n-doc) to develop nutrition initiatives aimed at helping to manage diabetes.the collaboration - which focuses on increasing consumers’ awareness and knowledge of their diets - will see nestlé work with n-doc to understand the impact of local diets and changing lifestyles on the increasing incidence of the disease in india.
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excess fat around the abs can turn the body\'s defense system against you, leading to heart and other diseases. australian researchers found that for obese individuals, shedding just 10 pounds could straighten out an off-balance immune system. the immune system is made up of many different kinds of cells that protect the body from germs, viruses and other invaders. these cells need to co-exist in a certain balance for good health to be maintained.
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food marketers are vying harder than ever for your shopping dollar. they use any of 14,000 additives to make their products last longer, taste fresher or seem more appealing. the health effects of these compounds, especially in combination, are only gradually becoming apparent.read all the details in our four part series highlighting the worst compounds typically added to our food supply.trans fattrans fats are the result of an industrial process that transforms liquid vegetable oils into a more solid product.
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if you ever feel tempted to go for a cheeseburger, fries and a soft drink, consider this: along with the fast food, you are ordering up an increased risk of heart disease, diabetes and obesity. but the opposite is true, too. according to a new university of florida (uf) study, if you stay away from processed and fast foods and instead eat a lot of veggies, nuts and fruits, you will actively be helping to prevent or reverse harmful metabolic processes in your body.
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researchers looking at the rising occurrence of obesity in the uk population will present some interesting findings - including the affects of carbohydrates levels on the diet, portion sizes and more insight into 'friendly' fats - at a conference being held in london today. as uk waistbands expand out of control, the meeting of the association for the study of obesity will take a look at some of the most current research into this disease.
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Coca.Cola
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PEPSI
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Mcdonald
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Nestle
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Mars
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Baskin & Robins
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Nutrika
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Mumika
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Chika
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the government is telling half of the u
a study linking consumption of 