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study gives light at the end of the peanut allergy tunnel
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gradual exposure to peanut may put an end to peanut allergy, if results of a small study from cambridge are followed by similar positive results. scientists from addenbrooke’s hospital in cambridge exposed four peanut-allergic children to gradually increasing quantities of peanut protein, and found that all the children can now tolerate about 800 mg grams of protein, which is the equivalent to five peanuts, per day. dr andy clark and his co-workers report their results of their study in the journal allergy . although the study is small, the implications could essentially be huge. peanut allergies are rising in humans, with an estimated 2.5 million people in europe and the us now vulnerable to the food allergy. there is no current cure for food allergy and vigilance by an allergic individual is the only way to prevent a reaction but a peanut allergy can be so severe that only very tiny amounts can be enough to trigger a response. current recommendations in many countries, such as the uk and the us, for would-be mothers are to avoid peanuts during pregnancy, breastfeeding, and infancy. with peanut allergy potentially fatal for some people, food manufacturers are already bound by certain regulations, depending on the country, to highlight possible allergens in a food product, such as the eu’s labelling directive 2000/13/ec. four children give hope dr clark and his co-workers recruited the four children aged 12, 13, 9, and 13, and investigated if peanut oral immunotherapy (oit) could induce clinical tolerance to peanut protein. an initial challenge confirmed the presence of peanut allergy in the children, with one of them experiencing anaphylaxis that required an injection of adrenaline. these initial tests revealed dose thresholds ranging from five to 50 mg, which is the equivalent to between 0.025 and 0.25 of a peanut. the children then began oit as daily doses of peanut flour. the doses increased fortnightly from 5 to 800 mg of protein. six weeks later, the oral challenge was repeated, and the new dose threshold values calculated. at the same time, subjects continued daily treatment. during the post intervention challenges, the four children were found to tolerate at least 10 whole peanuts, or 2.4 grams of protein, said the researchers. this equated to a dose threshold increase of 48-, 49-, 55- and 478-fold for the four subjects. current state-of-play “each subject is currently tolerating approximately 800 mg protein (five peanuts) per day, and can tolerate at least double that amount on oral challenge,” wrote clark and his co-workers. “tolerance may be lost if subjects were to stop oit at this stage, and it is likely that long-term maintenance is required, as for other forms of immunotherapy. “follow-up studies are therefore required to examine the duration and frequency of maintenance therapy required to induce long-term tolerance,” they concluded. early exposure may be vital a recent study comparing incidence of peanut allergy in jewish children in the uk and israel (where no recommendations for peanut avoidance exist) showed that children in the uk were 10 times more likely to suffer from peanut allergy than their israeli counterparts. findings in the journal of allergy and clinical immunology showed that 69 per cent of israeli children were consuming peanut, while only ten per cent of the children in the uk were eating peanuts. source: allergy published online ahead of print, doi: 10.1111/j.1398-9995.2009.01982.x "successful oral tolerance induction in severe peanut allergy" authors: a. t. clark, s. islam, y. king, j. deighton, k. anagnostou, p. w. ewan
Source :Food Ingredients Food Science - Additives, Flavours, Starch
Date :
20
February
2009
Category :
Fruits And Vegetables
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use of a common symbol to indicate the presence of individual allergens in food and personal care products could help allergy sufferers identify products to avoid – especially in multi-lingual communities, say specialists from imperial college. incidence of allergy has been increasing. in the uk some 1.8 per cent of children now have peanut allergy; in the us, 8 per cent of children and 4 per cent of adults have a food allergy.
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fears over the dangers of peanut allergy, a potentially deadly allergy for certain people, are becoming sensationalist and hysterical, according to a harvard professor. a level-headed approach is needed before the situation spirals out of control, wrote professor nicolas christakis from harvard medical school in the british medical journal . the food industry is already bound by certain regulations, depending on the country, to highlight possible allergens in a food product, such as the eu’s labelling directive 2000/13/ec.
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avoiding peanuts in infancy and early childhood may increase the risk of developing peanut allergy, says a joint british-israeli study. children in the uk, where recommendations are to avoid peanuts during pregnancy, breastfeeding, and infancy, were 10 times more likely to suffer from peanut allergy than their israeli counterparts, according to a new study published in the journal of allergy and clinical immunology .
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outgrowing allergies to milk and egg may no longer be the case, as new research from the us suggests the allergies are more persistent than first thought. over the course of 13 years, researchers from the johns hopkins children's center followed 800 patients with milk allergy and nearly 900 with egg allergy, and found that the allergies persisted well into the school years and beyond.
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the uk's food standards agency should ensure appropriate consideration is given to allergens by the european commission, as part of if its review of food labelling, say peers. however the house of lords' committee on science and technology has expressed concern that allergen labelling, as part of the on-going eu review of food labelling requirements, is not be specific enough.
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patients with kidney disease may be at danger from a ‘hidden threat’ of phosphorous additives found in processed and fast foods, says a new study from the us. writing in the new issue of the journal of the american medical association (jama), ohio-based scientists report that additional phosphorous, such as sodium phosphate or pyrophosphate, may be too much for a compromised kidney to expel.
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